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KMID : 0355619930190010063
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Journal of Korean Association of Oral and Maxillofacial Surgeons
1993 Volume.19 No. 1 p.63 ~ p.78
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An experimental study on tissue response of the freeze-dried and demineralized human bone
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Abstract
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To evaluate the osteoinductive capacity of the bank bone procured from the oral and maxillofacial surgery patients, the histological and ultrastructural features of tissue response were studied after implantation of decalcified and undecalcified
human
bone which were partially decalcified in 0.5N HC1, approximately 1mm3 size with freeze-drying. The recipient site was chosen to a calvarial bone of the New Zealand white rabbit. Demineralized and undemineralized bone matrix showed different
tissue
response around the grafted matrix. After implantation of the demineralized bone matrix, there were no evidence of foreign body reaction and resorption, but were newly synthesized woven bone composed of irregular collagen fibers in early stage
compared
with the undemineralized bone matrix which showed osteoclast-like giant cells and reversal lines.
At later stage of demineralized bone matrix, Woven bone and scattered capillary formation have shown with a hematopoietic marrow and compact bone with the evidence of remodelling.
Activities of collagen synthesis were not seen in typical osteoblasts but in fibroblastic or mesenchymal cells of the recipient sites.
There were no significant differences of cellular activities between the demineralized and undemineralized bone groups in later stage.
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KEYWORD
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